Effect on The Physiological Changes in Terms of Force, Contraction and Relaxation of Failing Left Ventricle

This study investigates the physiological changes in force contraction and relaxation of the failing left ventricle, addressing the gap in understanding myocardial dysfunction in heart failure. Using a prospective design, 65 cardiac tissue samples were analyzed from June 2022 to April 2023, categorized into non-failing, failing ischemic, and failing non-ischemic groups. The methodology involved preparing cardiac trabeculae and assessing contractile properties at a baseline frequency of 1 Hz. Findings indicate that failing myocardium exhibits lower active developed force, prolonged time to peak tension, and slower relaxation dynamics compared to non-failing myocardium, with statistically significant differences noted primarily in the failing non-ischemic group. These results suggest impaired contractile function and altered myocardial kinetics in failing hearts, providing critical insights for developing targeted therapeutic interventions to enhance cardiac performance in heart failure patients.