Publication Details
Abstract
Encephalitis, it is a brain tissue inflammation caused by a *viral infection* (common), *autoimmune encephalitis* (sometimes), and because of *parasites or bacteria* (rarely). Heat shock protein 70 (HSP70) is the primary molecular chaperone involved in maintaining protein quality, engaging in various cellular activities through its interaction with diverse client proteins, and serves as the main coordinator of the cellular proteostasis system. We aimed to assess serum HSP70 levels in the present study and to find the correlations with other biochemical markers in individuals with encephalitis. A case-control study was done, including 120 Iraqi participants in Diwaniyah city (60 individuals diagnosed with encephalitis, 60 individuals diagnosed as controls). Various parameters and HSP70 levels were measured in all subjects. Comparison of QUICKI and also TGF-β, as well as *FSG* and - HSP70, and insulin, in addition to HOMA-IR levels - in encephalitis with control and showed - increased with significantly - in encephalitis - compared -to- control. A strong *significant* positive correlation - *showed* between HSP70 and - FSG and - TGF-β, also insulin, in addition to HOMA-IR levels. Conclusions: * HSP70 levels can be used to identify corneal fibrosis as an early diagnostic marker in encephalitis patients.