Publication Details
Abstract
Metabolic syndrome (MetS) is a constellation of related cardiometabolic risk factors which increases the likelihood of developing cardiovascular diseases. NGAL, a 25 kDa protein released by neutrophils is associated witih various inflammatory and metabolic diseases. It has recently been demonstrated that all these diseases are primarily due to an increased burden of oxidative stress (OS) resulting from a switch in redox regulation. It appears that oxidative stress is the cause and even result of obesity and associated diseases. the present study conducted in kirkuk governorate during the period from December 2024 to June 2025, a measurement of the neutrophil gelatinase-associated lipocalin (NGAL) levels and lipid profile concentrations as well as total antioxidant capacity(TAC),, nitric oxide (NO), fasting serum glucose(FSG), glycated hemoglobin (HbA1c) and homocysteine that were done in 62 subjects with metabolic syndrome group and 30 healthy control group aged between (20–60) years old for both groups. It was found that: compared to the control group, average blood serum levels of Neutrophil gelatinase-associated lipocalin NGAL, FSG, LDL-B, TG concentrations of (LDL), VLDL and cholesterol and HbAc1 in people suffering with MS were statistically higher (p≤ 0.05). Results Serum NO, HDL as well as TAC were significantly decreased (p≤ 0.05) in patients with MetS than healthy controls.