Synthesis and In vitro of novel Metals ion Complexes, with the Assessment of their Anti-cancer Activity

Novel different complexes, such as gold(III) and nickel(II), were synthesized by using α-aminoamide as a ligand, and gold(III) and nickel (II) metal ions and characterized by spectroscopy, such as FTIR, 1H-NMR, and UV-visible, in addition to molar conductivity. The Ligand derivative (L) has been synthesized have been synthesized by mixt a derivative (E) as an alpha amino nitrile compound with concerted sulphuric acid. The well-aligned donor atoms (N2) of ligand (L) interacted with gold(III) and nickel(II) ions, which are proposed to exhibit square planar geometry.  The viability of WRL68 cells decreased with increasing doses (400–12.5 μg/mL), showing toxicity at higher concentrations. Lower doses (100, 50, 25 μg/mL) were nontoxic. The derivative C2 exhibited higher toxicity than the derivative C1. In MCF-7 cells, viability decreased with dose, with derivative C2 more cytotoxic than derivative C1.