Publication Details
Abstract
Cyclodextrins (CDs) show superior ability to form drug aggregates/CDs, as their physical and chemical properties are further improved without changing the properties of the drug and its composition. This formed complex increases the solubility and complexation capacity. The formed complex increases the. Solubility and complexation capacity, as well as the exchange between the complex (drug/CDs) and the medium near the biological membranes, in which the affinity between the hydrophobic groups in the drug and the biological membrane is greater than the affinity of the drug to the inner surface of the cyclodextrins, and thus the drug is released and penetrates the biological wall of the cell. Inclusion complex It has high solubility in aqueous solutions as well as plays an important role in bioavailability and can change thermodynamic activity, dissociation, or dissolution rate of the drug, as well as the rate and extent of drug absorption, and the complex formation of Benzamidazol/β-cyclodextrin was confirmed by SEM.