Innovative Synthesis and Structural Elucidation of Imidazo[1,2-a]pyridines: Incorporating Molecular Docking for Targeted Interactions

A new group of 3-substituted heterocyclic molecules with bridge head nitrogen has been made using several steps of reactions. A well-known method was used to make the first 2-substituted heterocyclic compounds of pyridine. It involves mixing 2-amino pyridine with (2-bromo-1-(4-phenoxyphenyl)ethan-1-one). Using the Vilsmeier-Haack reaction, the carbaldehyde group was added to position-3 of the synthetic 2-substituted imidazo/pyridine rings.  It was also found that 3-carbaldehyde reacted with 2-amino pyridine, creating new imidazo/pyridine rings. All of the molecules that were made were characterized using FT-IR, 1H-NMR, and 13C-NMR spectroscopy.The synthesized substances were looked at more closely using molecular docking to see how well they worked in stopping oxidoreductase, an enzyme that is linked to the growth of breast cancer.